Cocaine Use Reduction with Buprenorphine (CURB): Rationale, design, and methodology

Conclusions: This research using 2 medications will demonstrate whether BUP, administered in the presence of XR-NTX, reduces cocaine use in adults with cocaine dependence and opioid use disorders and will demonstrate if XR-NTX prevents development of physiologic dependence on BUP. (Source: Contemporary Clinical Trials)