Author: news_poster
Posted: Tue Aug 23, 2011 2:00 am
Authors: Somaini L, Saracino MA, Marcheselli C, Zanchini S, Gerra G, Raggi MA
Abstract
The sublingual combination of buprenorphine and naloxone (Suboxone(®)) and Methadone Maintenance Therapy have been found effective in treating heroin addiction. A new analytical method suitable for the simultaneous determination of buprenorphine, norbuprenorphine, methadone and naloxone in human plasma by means of liquid chromatography with coulometric detection has been developed. The chromatographic separation was achieved with a phosphate buffer-acetonitrile mixture as the mobile phase on a cyano column. The monitoring cell of the coulometric detector was set at an oxidation potential of +0.600V. A rapid clean-up procedure of the biological samples using a microextraction by packed sorbent te…<div><p>MedWorm Message: Find out how you can <a>get your message posted here and on over 100,000 other medical web pages</a> in just a couple of days, plus support MedWorm at the same time.</p></div>
Source: MedWorm Query: Buprenorphine
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