Author: news_poster
Posted: Wed Jun 01, 2011 2:00 am
Abstract: A liquid chromatography tandem mass spectrometry method is described for the analysis of buprenorphine and norbuprenorphine in whole blood. Linearity was achieved between 0.2–5ng/g for buprenorphine and 0.5–5ng/g for norbuprenorphine. Stability studies on spiked whole blood and an authentic sample showed no degradation of buprenorphine- and norbuprenorphine-glucuronide to their respective aglycones. Buprenorphine and norbuprenorphine showed some degradation when stored at 4°C for three weeks, but was stable when stored at −20°C for 4 weeks. The method was applied to forensic cases of driving under the influence of drugs (DUID) and petty drug offences (PDO) during 2007–2009. Out of 2459 cases analyzed, 322 were positive for both buprenorphine and norbuprenorphine (13%), …
Source: MedWorm Query: Buprenorphine
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