Author: news_poster
Posted: Thu Dec 08, 2011 3:00 am
In this study, perinatal exposure to low levels of this drug induced accelerated and increased expression of myelin basic proteins (MBPs), cellular and myelin components that are markers of mature oligodendrocytes. In contrast, supra-therapeutic drug doses delayed MBP brain expression and resulted in a decreased number of myelinated axons. We have now found that this biphasic-dose response to buprenorphine can be attributed to the participation of both the l-opioid receptor (MOR) and the nociceptin/orphanin FQ receptor (NOP receptor) in the oligodendrocytes. This is the first study showing the potential role of the NOP receptor in myelination. High levels of opiate exposure could negatively disrupt the normal interplay between these two systems altering the developmental pattern of brain m…
Source: MedWorm Query: Buprenorphine
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