Author: hatmaker510
Posted: Thu Sep 01, 2011 7:05 am
I wanted to add this from Dr. Junig about "conversion":
"…the problem is the non-linear kinetics of buprenorphine. You can’t just extrapolate out with bupe, like you can with agonists that don’t have a ‘ceiling effect’.
In other words, one mg of buprenorphine is as potent as about 20 mg of methadone, 2 mg of buprenorphine is as potent as 30-40 mg of methadone, and 4 mg, 8 mg, or 24 mg of buprenorphine are all as potent as 30-40 mg of methadone! The calculator works fine as long as you use doses for buprenorphine below the ‘ceiling’ effect– say down in the microgram ranges. But you cannot use those numbers to project out in a straight line– because the potency of buprenorphine, being a ‘partial agonist’, doesn’t follow a straight line."
(This was posted in this thread: http://suboxforum.com/viewtopic.php?p=27384#27384)
