Author: mayunholdup
Posted: Sun Jul 31, 2011 3:49 am
I should have clarified: Yes, Naloxone can be life-saving in overdose situations, but the amount of naloxone in Suboxone is not nearly the amount you would need to take to rip Buprenorphine from your receptors.
As for the first time you injected Suboxone, you said you were off heroin for three days, my question is how long were you using heroin? Even after three days, you could’ve had some H floating around in there or built up in your receptors, not enough to take out of withdrawal, but a trace amount that when the Naloxone hit your blood stream, it was literally a shock to your system since it was the first time you hadn’t had even a trace amount of opiates in your system.
Still though, my main point is that if you’re on daily Suboxone maintenance, you could take your medication however you wanted without any ill effects, meaning there is no difference between being on a daily regime of Suboxone or Subutex.
Post Edit: I think I know why you got sick the first time now! The first time, your receptors weren’t completely bare when you injected the Suboxone pill. As you know, when you inject Suboxone you receive the full effect of Naloxone versus if you take it under the tongue. When heroin crosses the blood brain barrier, it basically turns into Morphine. Naloxone structure closely resembles that of oxymorphone, which when it hits the brain, also turns into Morphine. So, your brain see’s the Naloxone and instantly recognizes it as heroin and and it’s directed to your receptors, where it attaches, ripping off any trace amount of heroin you had in your system, sending your body into further withdrawals and basically shock from having your receptors ripped clean. Eventually, the Bupe found the way into your receptors made you feel better soon after.
As for the second time you did it…Did you just do heroin once or a few time, then did Suboxone, or where you full blown addiction when you did it? Since, if you just did heroin once…or even a few times it wouldn’t build up in your system meaning you would experience no withdrawal if you stopped taking the heroin.
I also read this interesting tidbit from the SubDoc’s other site at suboxonetalkzone.com:
Suboxone and Subutex are interchangable; there is no difference between the subjective experiences of them, save for the lack of flavoring in Subutex and the ‘fruity flavor’ of Suboxone. The naloxone in Suboxone is not absorbed from the mouth, and the naloxone that is absorbed from the intestine is broken down very efficiently by the liver, so that very little gets into the systemic circulation.
The effect one has to the initial dose of buprenorphine, whether it comes from Suboxone or from Subutex, depends on the person’s level of tolerance. If a person has a very high tolerance, he will feel withdrawal. If the tolerance is very low, the person will feel a ‘high’. In either case, they will adjust to the dose of buprenorphine within a few days and feel normal. In the case of the person who initially felt a buzz, the person becomes tolerant to the buprenorphine; in the case of the person who felt withdrawal, the person ‘recovers’ from withdrawal as his opiate receptors adjust to the reduced level of opiate stimulation
