Author: news_poster
Posted: Thu Jul 07, 2011 2:00 am
Authors: Nikolaou P, Papoutsis I, Athanaselis S, Pistos C, Dona A, Spiliopoulou C
Buprenorphine (BUP) is used for the maintenance of opioid-addicted pregnant women. Because BUP and its main metabolite nor-BUP are excreted into breast milk, a sensitive and specific GC/MS method has been developed, optimized and validated for their determination in breast milk. BUP-d4 was used as internal standard. The sample preparation includes combination of protein precipitation with solid-phase extraction and derivatization (acetylation). The absolute recovery for both analytes was found to be higher than 87.3%. The limits of detection and quantification were 0.07 and 0.20 µg/L, respectively. The calibration curves were linear within the dynamic range 0.20-20.0 µg/L, with a correlation coeffic…
Source: MedWorm Query: Buprenorphine
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